Strategies for Neuromuscular Blockade in Patients with Myotonic Dystrophy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F15%3A00063246" target="_blank" >RIV/65269705:_____/15:00063246 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/15:00083686

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Strategies for Neuromuscular Blockade in Patients with Myotonic Dystrophy

Original language description

Myotonic dystrophy is a chronic, slowly progressing, highly variable, inherited multisystemic disease. It is characterized by wasting of the muscles, cataracts, heart conduction defects, endocrine changes, slow gastric and bowel emptying, and myotonia. Patients with myotonic dystrophy show myotonic responses to succinylcholine and neostigmine, and increased sensitivity to non-depolarising muscle relaxants. Sugammadex, a novel drug developed specifically for the rapid reversal of neuromuscular blockade induced by steroidal non-depolarising muscle relaxants, would be useful in patients with muscular disorders. The use of sugammadex was reported in a patient with myasthenia gravis and Huntington's disease. During 2012-2014 were reported successful use of sugammadex in some cases for caesarean section, for laparoscopic ovarian cystectomy and for urgent abdominal surgery. In this chapter we would like to present, based on best evidence, strategy of neuromuscular blockade for the patient with myotonic dystrophy. We will report physiology and pathophysiology of neuromuscular transmission and potentially suitable approaches for neuromuscular blocking agent use. We will especially focus on premedication, induction of anaesthesia, response to muscle relaxants, reverse of neuromuscular blockade, the crucial points of safe anaesthesiological care, and other perioperative triggers. Moreover we will discuss use of neuromuscular blockade and its reverse in patients with myotonic dystrophy undergoing some special surgeries - caesarean section, scoliosis surgery and general surgery. Patients with myotonia may have abnormal responses to anaesthetic agents. An increased sensitivity to non-depolarising muscle relaxants is described in patients with myotonic dystrophy. Anti-cholinesterase drugs (neostigmine) can lead to myotonic reaction.

Czech name

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Czech description

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Type

C - Chapter in a specialist book

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/NT13906" target="_blank" >NT13906: Modern myorelaxation procedure and reversal of neuromuscular blockade with general anesthesia for caesarean section.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name

Myotonic dystrophies: epidemiology, diagnosis and therapeutic challenges

ISBN

978-1-63482-905-2

Number of pages of the result

11

Pages from-to

1-11

Number of pages of the book

198

Publisher name

Nova Science Publishers, Inc.

Place of publication

New York

UT code for WoS chapter

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