Effects of acetylsalicylic acid on coagulation tests and haptoglobin concentrations in rabbits with permanent transvenous pacing

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F16%3A00065946" target="_blank" >RIV/65269705:_____/16:00065946 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/16:00092318 RIV/62157124:16170/16:43874456 RIV/62157124:16370/16:43874456
Result on the web
<a href="http://www.agriculturejournals.cz/web/vetmed.htm?volume=61&firstPage=348&type=publishedArticle" target="_blank" >http://www.agriculturejournals.cz/web/vetmed.htm?volume=61&firstPage=348&type=publishedArticle</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.17221/33/2016-VETMED" target="_blank" >10.17221/33/2016-VETMED</a>

Result language
angličtina
Original language name
Effects of acetylsalicylic acid on coagulation tests and haptoglobin concentrations in rabbits with permanent transvenous pacing
Original language description
The aim of this study was to evaluate changes in coagulation tests, haptoglobin concentrations and leukocyte counts in rabbits with right-ventricle pacing medicated with acetylsalicylic acid (ASA). Blood was collected from 35 non-anaesthetised males from the jugular vein at baseline, one and two months after pacemaker implantation. Animals were divided into two groups: non-medicated and medicated with ASA. Total leukocyte and platelet counts were measured on an automatic veterinary flow cytometry haematological analyser. Prothrombin time, activated partial thromboplastin time, fibrinogen levels and D-dimers were determined from citrated blood. We found significantly elevated activated partial thromboplastin times and prothrombin times in ASA in comparison to the control group, but not within the ASA group over time. We also observed a decrease in platelet counts in the control group over time, but not in comparison to the ASA group. No significant changes in total leukocyte counts and haptoglobin concentrations were detected. Medication with ASA may alter coagulation profiles in rabbits with permanent transvenous pacing.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Project
<a href="/en/project/NT14591" target="_blank" >NT14591: Plasma markers of coagulation activation in patients with endocardial electrode~</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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