MicroRNA-210 expression during childbirth and postpartum as potential biomarker of acute fetal hypoxia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F18%3A00068759" target="_blank" >RIV/65269705:_____/18:00068759 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/18:00101847
Result on the web
<a href="http://phdretreat.ceitec.cz/ceitec-phd-and-postdoc-retreat-2018/" target="_blank" >http://phdretreat.ceitec.cz/ceitec-phd-and-postdoc-retreat-2018/</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
MicroRNA-210 expression during childbirth and postpartum as potential biomarker of acute fetal hypoxia
Original language description
Objective: To explore whether miR-210 expression can be used as a diagnostic and prognostic marker in acute fetal hypoxia. Methods: Whole blood samples of 29 women and their fetuses without hypoxia and 24 women and their fetuses with hypoxia were analysed in this study. Reverse transcrip-tion and quantitative real-time PCR were used to measure the expression of miR-210. Expression level differences between the control and hypoxic group in labour time and postpartum change fold were analysed by standard statistical tests. Results: We confirmed that miR-210 is significantly more upregulated in fetal blood with acute hypoxia when compared to maternal blood (P<0.001). Furthermore, there was significant up-regulation in miR-210 level in the hypoxic group when compared to the control non-hypoxic group (P<0.05) in both maternal and fetal blood. Our results did not confirm a significant difference in postpartum miR-210 clearance level 2, 8, 24 or 48 hours after labour. Conclusions: Our study confirmed miR-210 upregulation in the blood of pregnant women with acute fetal hypoxia at the time of labour compared to pregnant women without acute fetal hypoxia. Additional investigation should be done to determine miR-210 clearance.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
<a href="/en/project/TE02000058" target="_blank" >TE02000058: Center of competence for molecular diagnostics and personalized medicine</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů