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MicroRNA-210 expression during childbirth and postpartum as a potential biomarker of acute fetal hypoxia

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F19%3A00071263" target="_blank" >RIV/65269705:_____/19:00071263 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14740/19:00108369

  • Result on the web

    <a href="https://biomed.papers.upol.cz/pdfs/bio/2019/03/11.pdf" target="_blank" >https://biomed.papers.upol.cz/pdfs/bio/2019/03/11.pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.5507/bp.2018.075" target="_blank" >10.5507/bp.2018.075</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    MicroRNA-210 expression during childbirth and postpartum as a potential biomarker of acute fetal hypoxia

  • Original language description

    OBJECTIVE: To explore whether miR-210 expression can be used as a diagnostic and prognostic marker in acute fetal hypoxia. METHODS: Whole blood samples of 29 women and their fetuses without hypoxia and 24 women and their fetuses with hypoxia were analysed in this study. Reverse transcription and quantitative real-time PCR were used to measure the expression of miR-210. Expression level differences between the control and hypoxic group in labour time and postpartum change fold were analyzed by standard statistical tests. RESULTS: We confirmed that miR-210 is significantly more upregulated in fetal blood with acute hypoxia when compared to maternal blood (P Conclusions: Our study confirmed miR-210 upregulation in the blood of pregnant women with acute fetal hypoxia at the time of labour compared to pregnant women without acute fetal hypoxia. Additional investigation should be done to determine miR-210 clearance and the possibility of using miR-210 as a diagnostic and prognostic marker.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30100 - Basic medicine

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biomedical papers

  • ISSN

    1213-8118

  • e-ISSN

  • Volume of the periodical

    163

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    6

  • Pages from-to

    259-264

  • UT code for WoS article

    000489991000011

  • EID of the result in the Scopus database

    2-s2.0-85072702220