Vulvar cancer recurrence - an analysis of prognostic factors in tumour-free pathological margins patients group
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F18%3A00069190" target="_blank" >RIV/65269705:_____/18:00069190 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/18:00104063
Result on the web
<a href="https://journals.viamedica.pl/ginekologia_polska/article/view/58403" target="_blank" >https://journals.viamedica.pl/ginekologia_polska/article/view/58403</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5603/GP.a2018.0073" target="_blank" >10.5603/GP.a2018.0073</a>
Alternative languages
Result language
angličtina
Original language name
Vulvar cancer recurrence - an analysis of prognostic factors in tumour-free pathological margins patients group
Original language description
Objectives:To evaluate risk factors associated with the local recurrence of invasive squamous cell vulvar cancer in patient group with tumor-free pathological margins. Material and methods: This is a retrospective analysis of 47 patients who underwent surgical treatment at University Hospital Brno, the Czech Republic between 2007 and 2014. 24 patients were classified as IB stage and three as II stage. A further 20 patients representing stage III showed the metastatic involvement of regional lymph nodes. Seven prognostic factors were analyzed in relation to local tumour recurrence: tumour size, margin distance, depth of invasion, lymphovascular space involvement (LVSI), midline involvement, metastatic lymph nodes and FIGO stage. Results: All prognostic factors were found to be statistically significant with respect to the risk of local recurrence. The highest risk of local recurrence was observed for the depth of invasion > 5 mm (HR, 12.42 [95% CI; 3.44-44.841) and for the presence of LVSI (HR, 10.83 [95% CI; 3.87-30.28]).The study also established a clear difference in the risk of local recurrence between patient groups with resection margin < 8 vs. >= 8 mm (HR, 4.91 [95% CI; 1.73-13.93; p = 0.003]. Conclusions: Tumour-free pathological margin of >= 8 mm is a major prognostic factor of local recurrence which can be influenced by the surgeon. A perfect knowledge of the extent of the disease prior to surgery supports adequately radical surgical trends. The emphasis is given on adequate radicality as well as on the reduction of overtreatment without worsening prognosis by simultaneously preserving the quality of life.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30214 - Obstetrics and gynaecology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Ginekologia Polska
ISSN
0017-0011
e-ISSN
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Volume of the periodical
89
Issue of the periodical within the volume
8
Country of publishing house
PL - POLAND
Number of pages
8
Pages from-to
424-431
UT code for WoS article
000444810900004
EID of the result in the Scopus database
2-s2.0-85052687294