Sex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend intervals

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F19%3A00071829" target="_blank" >RIV/65269705:_____/19:00071829 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/19:00112966

Result on the web

<a href="https://www.nature.com/articles/s41598-019-56328-8.pdf" target="_blank" >https://www.nature.com/articles/s41598-019-56328-8.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-019-56328-8" target="_blank" >10.1038/s41598-019-56328-8</a>

Result language

angličtina

Original language name

Sex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend intervals

Original language description

To facilitate the precision of clinical electrocardiographic studies of J-to-Tpeak (JTp) and Tpeak-to-Tend (Tpe) intervals, the study investigated their differences between healthy females and males, and between subjects of African and Caucasian origin. In 523 healthy subjects (254 females; 236 subjects of African origin), repeated Holter recordings were used to measure QT, JT, JTp, and Tpe intervals preceded by both stable and variable heart rates. Subject-specific curvilinear regression models were used to obtain individual QTc, JTc, JTpc and Tpec intervals. Rate hysteresis, i.e., the speed with which the intervals adapted after heart rate changes, was also investigated. In all sex-race groups, Tpe intervals were not systematically heart rate dependent. Similar to QTc intervals, women had JTc, and JTpc intervals longer than males (difference 20-30 ms, p &lt; 0.001). However, women had Tpec intervals (and rate uncorrected Tpe intervals) shorter by approximately 10 ms compared to males (p &lt; 0.001). Subjects of African origin had significantly shorter QTc intervals than Caucasians (p &lt; 0.001). Gradually diminishing race-difference was found for JTc, JTpc and Tpec intervals. JTc and JTpc were moderately increasing with age but Tpe/Tpec were not. Rate hysteresis of JTp was approximately 10% longer compared to that of JT (p &lt; 0.001). In future clinical studies, Tpe interval should not be systematically corrected for heart rate and similar to the QT interval, the differences in JT, JTp and Tpe intervals should be corrected for sex. The differences in QT and JT, and JTp intervals should also be corrected for race. (C) 2019, The Author(s).

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10700 - Other natural sciences

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scientific Reports

ISSN

2045-2322

e-ISSN

—

Volume of the periodical

9

Issue of the periodical within the volume

DEC 27

Country of publishing house

GB - UNITED KINGDOM

Number of pages

16

Pages from-to

19880

UT code for WoS article

000508960600003

EID of the result in the Scopus database

2-s2.0-85077165038