Individually Rate Corrected QTc Intervals in Children and Adolescents

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F19%3A00071127" target="_blank" >RIV/65269705:_____/19:00071127 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/19:00110888

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fphys.2019.00994/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fphys.2019.00994/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fphys.2019.00994" target="_blank" >10.3389/fphys.2019.00994</a>

Result language

angličtina

Original language name

Individually Rate Corrected QTc Intervals in Children and Adolescents

Original language description

Accurate evaluation of the appearance of QTc sex differences during childhood and adolescence is intricate. Inter-subject differences of individual QT/RR patterns make generic heart rate corrections inaccurate because of fast resting heart rates in children. The study investigated 527 healthy children and adolescents aged 419 years (268 females, 50.9%). All underwent continuous ECG 12-lead monitoring while performing postural changes during a 70-min investigative protocol to obtain QT interval measurements at different heart rates. On average, more than 1200 ECG measurements (QT interval and its 5-min history of preceding RR intervals) were made in each subject. Curvilinear QT/RR regression involving intra-individual correction for QT/RR hysteresis were calculated in each subject. The projection of the QT/RR regressions to the heart rate of 60 beats per minute defined individually corrected QTc intervals. In males, gradual QTc shortening by about 15 ms appeared during the ages of 13-19 years synchronously with the incidence of secondary sex signs (p = 0.016). On the contrary, whilst gradual QTc prolongation by about 10 ms appeared in females, it occurred only during ages 16-19 years and was not related to the incidence of secondary sex signs (p = 0.18). The study also showed that in children and adolescents, linear QT/RR models fit the intra-subject data significantly more closely than the log-linear models (p &lt; 0.001). The study speculates that hormonal shifts during puberty might be directly responsible for the QTc shortening in males but that QTc prolongation in females is likely more complex since it was noted to follow the appearance of secondary sex signs only after a considerable delay.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30105 - Physiology (including cytology)

Project

<a href="/en/project/NV19-02-00197" target="_blank" >NV19-02-00197: Autonomic provocations for the assessment of cardiac repolarization dynamics in children and the progression of sex-related differences in adolescents.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Physiology

ISSN

1664-042X

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

AUG 2

Country of publishing house

CH - SWITZERLAND

Number of pages

15

Pages from-to

994

UT code for WoS article

000478600700002

EID of the result in the Scopus database

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