Sex and Rate Change Differences in QT/RR Hysteresis in Healthy Subjects

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F22%3A00075998" target="_blank" >RIV/65269705:_____/22:00075998 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/22:00126145

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fphys.2021.814542/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fphys.2021.814542/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fphys.2021.814542" target="_blank" >10.3389/fphys.2021.814542</a>

Result language

angličtina

Original language name

Sex and Rate Change Differences in QT/RR Hysteresis in Healthy Subjects

Original language description

While it is now well-understood that the extent of QT interval changes due to underlying heart rate differences (i.e., the QT/RR adaptation) needs to be distinguished from the speed with which the QT interval reacts to heart rate changes (i.e., the so-called QT/RR hysteresis), gaps still exist in the physiologic understanding of QT/RR hysteresis processes. This study was designed to address the questions of whether the speed of QT adaptation to heart rate changes is driven by time or by number of cardiac cycles; whether QT interval adaptation speed is the same when heart rate accelerates and decelerates; and whether the characteristics of QT/RR hysteresis are related to age and sex. The study evaluated 897,570 measurements of QT intervals together with their 5-min histories of preceding RR intervals, all recorded in 751 healthy volunteers (336 females) aged 34.3 +/- 9.5 years. Three different QT/RR adaptation models were combined with exponential decay models that distinguished time-based and interval-based QT/RR hysteresis. In each subject and for each modelling combination, a best-fit combination of modelling parameters was obtained by seeking minimal regression residuals. The results showed that the response of QT/RR hysteresis appears to be driven by absolute time rather than by the number of cardiac cycles. The speed of QT/RR hysteresis was found decreasing with increasing age whilst the duration of individually rate corrected QTc interval was found increasing with increasing age. Contrary to the longer QTc intervals, QT/RR hysteresis speed was faster in females. QT/RR hysteresis differences between heart rate acceleration and deceleration were not found to be physiologically systematic (i.e., they differed among different healthy subjects), but on average, QT/RR hysteresis speed was found slower after heart rate acceleration than after rate deceleration.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30105 - Physiology (including cytology)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Physiology

ISSN

1664-042X

e-ISSN

1664-042X

Volume of the periodical

12

Issue of the periodical within the volume

FEB

Country of publishing house

CH - SWITZERLAND

Number of pages

25

Pages from-to

814542

UT code for WoS article

000760998100001

EID of the result in the Scopus database

2-s2.0-85124937818