Comparing the Relationship between QT/RR Slope and Basal QTc in LQT1 Patients and Healthy Subjects

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F13%3A00421200" target="_blank" >RIV/68081731:_____/13:00421200 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Comparing the Relationship between QT/RR Slope and Basal QTc in LQT1 Patients and Healthy Subjects
Original language description
The dependency of the QT interval to the previous RR intervals has been widely studied, QT/RR slope and other modeling techniques revealed individual-specific relationship. In this work we studied the relationship between QT/RR slope and a basal QTc interval in 154 healthy subjects and in 97 patients with the inherited long QT syndrome type-1 (LQT1) to provide insights into the effect of the impairment of the outwardly directed delayed rectifier potassium current on the dynamic QT-RR coupling. QT/RR slope values show strong relationship to basal QTc interval in healthy (R=0.65; p<0.00001) and in LQT1 patients (R=0.56; p<0.00001). The dependency of QT/RR slope on QTc is steeper in healthy (a1=0.0016 0.0002) than in LQT1 (a1=0.0010 0.0002), p<0.0001. Thesteeper dependency on QTc in healthy preserves proper shortening of QT intervals during increased heart rate in healthy while in LQT1 patients the QT intervals does not adapt to increased heart rate sufficiently (lack of QT adaptation to
Czech name
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Czech description
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Project
<a href="/en/project/GAP102%2F12%2F2034" target="_blank" >GAP102/12/2034: Analysis of Relationship between Electrical Activity and Blood Flow at the Heart Ventricles</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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