Bortezomib and thalidomide treatment results in newly diagnosed transplant-ineligible multiple myeloma patients are comparable in long-term follow-up
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F19%3A00072329" target="_blank" >RIV/65269705:_____/19:00072329 - isvavai.cz</a>
Result on the web
<a href="https://www.linkos.cz/files/klinicka-onkologie/466/5660.pdf" target="_blank" >https://www.linkos.cz/files/klinicka-onkologie/466/5660.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.14735/amko2019445" target="_blank" >10.14735/amko2019445</a>
Alternative languages
Result language
angličtina
Original language name
Bortezomib and thalidomide treatment results in newly diagnosed transplant-ineligible multiple myeloma patients are comparable in long-term follow-up
Original language description
Background: Thalidomide-and bortezomib-containing regimens are widely used for transplant-ineligible newly diagnosed multiple myeloma patients. The aim of this study was to analyse the efficiency of thalidomide-or bortezomib-based regimens in long-term follow-up. Materials and methods: From 2008 to 2012, 142 transplant-ineligible newly dia gnosed multiple myeloma patients were analysed retrospectively. Bortezomib was administered at the standard dos ing of 1.3 mg/m2 weekly, and thalidomide was administered at a daily dose of 100 mg. Both drugs were combined with cyclophosphamide and dexamethasone. A total of 95 patients were treated with thalidomide and 47 with bortezomib. A median four cycles of treatment were administered in both groups. Results: In the thalidomide group, the over all response rate was 60.6%, the median progression-free survival (PFS) was 10.3 months (95% CI 7.4-13.2) and the median over all survival (OS) was 35.1 months (95% CI 23.9-46.3). In the bortezomib group, the over all response rate was 51.1%, the median PFS was 11.9 months (95% CI 8.8-15) and the median OS was 25.4 months (95% CI 9.3-41.6). There was a statistically significant difference in OS (p = 0.027), favour ing the cyclophosphamide/thalidomide/dexamethasone group, but the response rates and PFS intervals were not significantly different between both groups. The median follow-up in the thalidomide group was 35.1 months (95% CI 0.2-95.9) compared to 25.1 months (95% CI 0.4-60.6) in the bortezomib group (p = 0.004). The incidence of serious adverse events was comparable in both groups. Conclusion: In conclusion, the results of bortezomib treatment are comparable to thalidomide treatment under conditions of short administration. According to other clinical trials, long-term bortezomib treatment provides an additional advantage for PFS and OS.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Klinická onkologie
ISSN
0862-495X
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
6
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
8
Pages from-to
445-452
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85076692492