Impact of Sleep Apnea on Cardioembolic Risk in Patients With Atrial Fibrillation Data From the ESADA Cohort

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00074428" target="_blank" >RIV/65269705:_____/21:00074428 - isvavai.cz</a>
Result on the web
<a href="https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.120.030285" target="_blank" >https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.120.030285</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1161/STROKEAHA.120.030285" target="_blank" >10.1161/STROKEAHA.120.030285</a>

Result language
angličtina
Original language name
Impact of Sleep Apnea on Cardioembolic Risk in Patients With Atrial Fibrillation Data From the ESADA Cohort
Original language description
Background and Purpose: An accurate determination of the cardioembolic risk in patients with atrial fibrillation (AF) is crucial to prevent consequences like stroke. Obstructive sleep apnea (OSA) is a known risk factor for both AF and stroke. We aim to explore a possible association between OSA and an increased cardioembolic risk in patients with AF. Methods: We assessed data from the ESADA (European Sleep Apnea Database) cohort where patients with known AF and OSA were included. Parameters of OSA severity and related hypoxia like lowest Spo(2) and 4% oxygen desaturation index were analyzed. Patients were stratified according to their cardioembolic risk estimated with the CHA(2)DS(2)-VASc score. Results: From the initial cohort of 14 646 patients, a final set of 363 patients were included in the analysis. Indices of hypoxia during sleep were associated with increased CHA(2)DS(2)-VASc score (4% oxygen desaturation index 17.9 versus 29.6 versus 30.5 events/hour and the lowest Spo(2) 81.2 versus 77.8 versus 77.5% for low, moderate, and high cardioembolic risk, respectively, P<0.05). Conclusions: These results support the potential role of OSA-related hypoxia in the risk for cardioembolic complications such as stroke in patients with AF.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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