Tumor Characteristic Variations between Symptomatic and Asymptomatic Endometrial Cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00074453" target="_blank" >RIV/65269705:_____/21:00074453 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/21:00122021

Result on the web

<a href="https://www.mdpi.com/2227-9032/9/7/902" target="_blank" >https://www.mdpi.com/2227-9032/9/7/902</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/healthcare9070902" target="_blank" >10.3390/healthcare9070902</a>

Result language

angličtina

Original language name

Tumor Characteristic Variations between Symptomatic and Asymptomatic Endometrial Cancer

Original language description

Endometrial cancer is the most common gynecologic malignancy in Europe and usually diagnosed in its initial stage owing to early symptoms of abnormal bleeding. There is no population screening for this disease, although it can sometimes be accidentally diagnosed in asymptomatic patients. Our study aims to determine differences in clinical and tumor characteristics between an asymptomatic and symptomatic group of patients. This unicentric prospective observational study took place in University Hospital Brno between January 2016 and December 2019. A total of 264 patients met inclusion criteria (26% asymptomatic, 74% with reported symptoms). We did not find a statistically significant difference in clinical characteristics (menopausal status, parity, age, BMI, and serum level of CA 125) between groups. According to ultrasound examination, bleeding tumors were larger (19.5 vs. 12.7 mm, p &lt;= 0.001). Definitive histology results indicated more frequent lymphovascular space invasion (p &lt; 0.001), along with deep myometrial (p = 0.001) and cervical (p = 0.002) invasion. There was no difference in advanced stages of the tumor. We did not substantiate statistically significant difference in immunohistochemical profile (estrogen and progesterone receptors, L1 cell adhesion molecule, tumor protein p53), which is relevant for tumor recurrence risk and survival capacity. Our conclusions affirmed that bleeding occurs more often among patients with local tumor invasion into the myometrium and cervical stroma. Final International Federation of Gynecology and Obstetrics (FIGO) stage, histology, and immunohistochemical characteristics do not significantly affect symptom appearance.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30214 - Obstetrics and gynaecology

Project

<a href="/en/project/NU21-09-00031" target="_blank" >NU21-09-00031: Development of new effective strategy to identify high-risk women for endometrial cancer</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Healthcare

ISSN

2227-9032

e-ISSN

—

Volume of the periodical

9

Issue of the periodical within the volume

7

Country of publishing house

CH - SWITZERLAND

Number of pages

9

Pages from-to

902

UT code for WoS article

000677363300001

EID of the result in the Scopus database

2-s2.0-85111426503