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The experience with colorectal cancer screening in the Czech Republic: the detection at earlier stages and improved clinical outcomes

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F20%3A10416658" target="_blank" >RIV/00216208:11140/20:10416658 - isvavai.cz</a>

  • Alternative codes found

    RIV/00023001:_____/20:00080274 RIV/61383082:_____/20:00000920 RIV/00216208:11110/20:10416658 RIV/65269705:_____/20:00073191 and 2 more

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=0RNwrlBlhR" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=0RNwrlBlhR</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.puhe.2020.05.021" target="_blank" >10.1016/j.puhe.2020.05.021</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The experience with colorectal cancer screening in the Czech Republic: the detection at earlier stages and improved clinical outcomes

  • Original language description

    Objectives: Colorectal cancer (CRC) remains a major health burden. Although screening is recommended and considered beneficial, further data on its positive effects are needed for worldwide implementation. Study design: The aim of our national multicentre prospective observational study was to reveal and document clinicopathological differences in CRC diagnosed by screening and presented by disease symptoms as well as assess the efficiency of the screening programme in the Czech Republic. Methods: Between March 2013 and September 2015, a total of 265 patients were enrolled in 12 gastroenterology centres across the Czech Republic. Patients were divided into screening and symptomatic groups and compared for pathology status and clinical characteristics. Screening was defined as a primary screening colonoscopy or a colonoscopy after a positive faecal occult blood test in an averagerisk population. Results: The distribution of CRC stages was significantly (statistically and clinically) favourable in the screening group (predominance of stages 0, I and II) compared with the non-screening group (P &lt; 0.001). The presence of distant and local metastases was significantly less frequent in the screening group than in the symptomatic group (P &lt; 0.001). Patients in the screening group had a higher probability of radical surgery (RO) than those diagnosed based on symptoms (P &lt; 0.001). Systemic palliative treatment was indicated in two patients in the screening group compared with 23 patients in the non-screening group (P = 0.018). Conclusion: CRC diagnosed by screening disclosed less advanced clinicopathological characteristics and results in patients with a higher probability of radical surgery (RO) than diagnoses established based on symptoms, with subsequent management differing accordingly between both groups. These results advocate the implementation of a suitable worldwide screening programme.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30204 - Oncology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Public Health

  • ISSN

    0033-3506

  • e-ISSN

  • Volume of the periodical

    185

  • Issue of the periodical within the volume

    August

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    6

  • Pages from-to

    153-158

  • UT code for WoS article

    000576879200050

  • EID of the result in the Scopus database

    2-s2.0-85087358158