The experience with colorectal cancer screening in the Czech Republic: the detection at earlier stages and improved clinical outcomes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00539180" target="_blank" >RIV/68378041:_____/20:00539180 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0033350620301839?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0033350620301839?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.puhe.2020.05.021" target="_blank" >10.1016/j.puhe.2020.05.021</a>

Result language

angličtina

Original language name

The experience with colorectal cancer screening in the Czech Republic: the detection at earlier stages and improved clinical outcomes

Original language description

Objectives: Colorectal cancer (CRC) remains a major health burden. Although screening is recommended and considered beneficial, further data on its positive effects are needed for worldwide implementation.nStudy design: The aim of our national multicentre prospective observational study was to reveal and document clinicopathological differences in CRC diagnosed by screening and presented by disease symptoms as well as assess the efficiency of the screening programme in the Czech Republic.nMethods: Between March 2013 and September 2015, a total of 265 patients were enrolled in 12 gastroenterology centres across the Czech Republic. Patients were divided into screening and symptomatic groups and compared for pathology status and clinical characteristics. Screening was defined as a primary screening colonoscopy or a colonoscopy after a positive faecal occult blood test in an averagerisk population.nResults: The distribution of CRC stages was significantly (statistically and clinically) favourable in the screening group (predominance of stages 0, I and II) compared with the non-screening group (P < 0.001). The presence of distant and local metastases was significantly less frequent in the screening group than in the symptomatic group (P < 0.001). Patients in the screening group had a higher probability of radical surgery (RO) than those diagnosed based on symptoms (P < 0.001). Systemic palliative treatment was indicated in two patients in the screening group compared with 23 patients in the non-screening group (P = 0.018).nConclusion: CRC diagnosed by screening disclosed less advanced clinicopathological characteristics and results in patients with a higher probability of radical surgery (RO) than diagnoses established based on symptoms, with subsequent management differing accordingly between both groups. These results advocate the implementation of a suitable worldwide screening programme. (C) 2020 The Authors. Published by Elsevier Ltd on behalf of The Royal Society for Public Health.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30302 - Epidemiology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PUBLIC HEALTH

ISSN

1476-5616

e-ISSN

—

Volume of the periodical

185

Issue of the periodical within the volume

aug.

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

153-158

UT code for WoS article

000576879200050

EID of the result in the Scopus database

2-s2.0-85087358158