Antioxidants in patients living with HIV on antiretrovirals
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00074617" target="_blank" >RIV/65269705:_____/21:00074617 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/21:00557426 RIV/00216224:14110/21:00123033
Result on the web
<a href="https://mmsl.cz/artkey/mms-202102-0001_antioxidants-in-patients-living-with-hiv-on-antiretrovirals.php" target="_blank" >https://mmsl.cz/artkey/mms-202102-0001_antioxidants-in-patients-living-with-hiv-on-antiretrovirals.php</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.31482/mmsl.2021.005" target="_blank" >10.31482/mmsl.2021.005</a>
Alternative languages
Result language
angličtina
Original language name
Antioxidants in patients living with HIV on antiretrovirals
Original language description
Oxidative stress is considered predictors of diseases associated with aging (cardiovascular disease, neurodegenerative disease, malignancies, and others) in HIV-negative general population. Antioxidants were investigated in people living with HIV on antiretroviral treatment to determine whether they had an immunosenescent phenotype that might predispose to the development of premature age-related diseases. Clinical studies in this population are controversial. Methods The study was conducted among 213 subjects with HIV, including 172 subjects on antiretro-virals and 41 subjects before the initiation of treatment. The control group consisted of healthy HIV-negative adults. We compared the reduced glutathione and ferric reducing antioxidant power levels in HIV untreated and treated patients and controls. Significant differences were determined by appropriate statistical tests (t-test, Mann-Whitney U test, Kolmogorov-Smirnov test, ANOVA, Kruskal-Wallis test). Relationships between continuous variables were quantified using Spearman's rank correlation coefficient. Results Glutathione levels were significantly lower in the treated group compared with the untreated group and controls (P < 0.001). Differences in total antioxidant levels between groups were not found. Conclusions Significant decrease of antioxidants was found independent of the virologic status of HIV patients on antiretroviral treatment. Persistence of these abnormal parameters may contribute and predispose to the premature development of diseases associated with aging.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Vojenské zdravotnické listy
ISSN
0372-7025
e-ISSN
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Volume of the periodical
90
Issue of the periodical within the volume
2
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
7
Pages from-to
54-60
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85108181784