Oxidative stress, microparticles, and E-selectin do not depend on HIV suppression

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F25%3A00079594" target="_blank" >RIV/65269705:_____/25:00079594 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/26:00563505 RIV/00216224:14110/25:00140200

Result on the web

<a href="https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3607" target="_blank" >https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3607</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2024.002" target="_blank" >10.5507/bp.2024.002</a>

Result language

angličtina

Original language name

Oxidative stress, microparticles, and E-selectin do not depend on HIV suppression

Original language description

Background. Oxidative stress and inflammation are considered predictors of diseases associated with aging. Markers of oxidative stress, inflammation, and endothelial activation were investigated in people with HIV on antiretroviral treatment to determine whether they had an immunosenescent phenotype that might predispose to the development of premature age-related diseases. Patients and Methods. This study was conducted on 213 subjects with HIV. The control groups consisted of healthy HIV-negative adults. The level of oxidative stress was measured by assessing the production of malondialdehyde levels, which were detected by thiobarbituric acid reactive substance (TBARS) assay. The level of microparticles indicated the presence of inflammation and endothelial activation was measured by E-selectin levels. Significant differences were determined by appropriate statistical tests, depending on the distribution of variables. Relationships between continuous variables were quantified using Spearman&apos;s rank correlation coefficient. Results. TBARS, and microparticle and E-selectin levels were significantly higher in untreated and treated subjects with HIV compared with HIV-negative controls (P&lt;0.001). The levels of the investigated markers were not significantly different between untreated and treated patients and no significant correlation of these markers was found with CD4(+ )count, CD4(+)/CD8(+) ratio, and the number of HIV-1 RNA copies. Conclusions. Elevated markers of oxidative stress, inflammatory and endothelial activation were independent of the virologic and immunologic status of people with HIV. These results support the hypothesis that residual viremia in cellular reservoirs of various tissues is a key factor related to the premature aging of the immune system and predisposition to the premature development of diseases associated with aging.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30100 - Basic medicine

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical papers

ISSN

1213-8118

e-ISSN

1804-7521

Volume of the periodical

169

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

123-131

UT code for WoS article

001171815400001

EID of the result in the Scopus database

2-s2.0-105008387893