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Risk factors of thrombosis in a cohort of 206 patients with BCR-ABL1 negative myeloproliferative neoplasms

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00074910" target="_blank" >RIV/65269705:_____/21:00074910 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/21:00122606

  • Result on the web

    <a href="http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=7426&category_id=172&option=com_virtuemart&vmcchk=1&Itemid=1" target="_blank" >http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=7426&category_id=172&option=com_virtuemart&vmcchk=1&Itemid=1</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.4149/neo_2021_210729N1068" target="_blank" >10.4149/neo_2021_210729N1068</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Risk factors of thrombosis in a cohort of 206 patients with BCR-ABL1 negative myeloproliferative neoplasms

  • Original language description

    Thrombosis is the most common complication in BCR-ABL1 negative myeloproliferative neoplasms (MPN) that signifi-cantly impacts patients&apos; mortality. Generally, there is an agreement on risk factors that possibly contribute to the increased risk of thrombosis, including age, history of thrombosis, JAK2V617F mutation, and cardiovascular risk factors. This study retrospectively investigates MPN-related and patient-related variables in relation to the thrombosis occurrence in MPN. Our analyses show that JAK2V617F-mutated patients are at a significantly increased risk of thrombosis within five years before the MPN diagnosis point with a hazard ratio (HR) of 15.49 (p=0.006). In multivariate analyses, independent risk factors for thrombotic complications during the follow-up are history of thrombosis (HR=2.23, p=0.019), age over 60 years at diagnosis (HR=1.56, p=0.037), the presence of JAK2V617F mutation (HR=3.01, p=0.002), and tobacco smoking (HR=1.75, p=0.01). Our results support the multifactorial mechanism of thrombosis in MPN patients, which demands individual and complex management.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30205 - Hematology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Neoplasma

  • ISSN

    0028-2685

  • e-ISSN

  • Volume of the periodical

    68

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    SK - SLOVAKIA

  • Number of pages

    10

  • Pages from-to

    1341-1350

  • UT code for WoS article

    000729198300012

  • EID of the result in the Scopus database

    2-s2.0-85122546186