JAK2V617F mutation and circulating extracellular vesicles in essential thrombocythemia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F23%3A00078401" target="_blank" >RIV/65269705:_____/23:00078401 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/23:00130986
Result on the web
<a href="https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch221678" target="_blank" >https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch221678</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3233/CH-221678" target="_blank" >10.3233/CH-221678</a>

Result language
angličtina
Original language name
JAK2V617F mutation and circulating extracellular vesicles in essential thrombocythemia
Original language description
The clinical course of essential thrombocythemia (ET) is complicated with thrombosis which significantly impacts patients' mortality. Studies have identified JAK2(V617F) mutation as an independent risk factor for thrombosis. Circulating extracellular vesicles (EVs) were evaluated in several studies regarding myeloproliferative neoplasms and thrombosis as potential biomarkers. The present study investigates the relationship between JAK2(V617F) mutation and EVs levels in 119 ET patients. Our analyses revealed that JAK2(V617F-)positive patients are at a significantly increased risk of thrombosis within five years before the ET diagnosis (hazard ratio [95% CI]: 11.9 [1.7-83.7], P = 0.013), and that JAK2(V617F) mutation is an independent risk factor for thrombosis at ET diagnosis or during the follow-up (hazard ratio [95% CI]: 3.56 [1.47-8.62], P = 0.005). ET patients have higher levels of platelet-EVs, erythrocyte-EVs and procoagulant activity of EVs than the healthy population. Absolute and relative counts of platelet-EVs are increased in the presence of JAK2(V617F) mutation (P = 0.018, P = 0.024, respectively). In conclusion, our results support the role of JAK2(V617F) mutation in the pathogenesis of thrombosis in essential thrombocythemia through enhancing platelet activation.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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