Chromothripsis in Chronic Lymphocytic Leukemia: A Driving Force of Genome Instability

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00074911" target="_blank" >RIV/65269705:_____/21:00074911 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/21:00120226
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fonc.2021.771664/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fonc.2021.771664/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fonc.2021.771664" target="_blank" >10.3389/fonc.2021.771664</a>

Result language
angličtina
Original language name
Chromothripsis in Chronic Lymphocytic Leukemia: A Driving Force of Genome Instability
Original language description
Chromothripsis represents a mechanism of massive chromosome shattering and reassembly leading to the formation of derivative chromosomes with abnormal functions and expression. It has been observed in many cancer types, importantly, including chronic lymphocytic leukemia (CLL). Due to the associated chromosomal rearrangements, it has a significant impact on the pathophysiology of the disease. Recent studies have suggested that chromothripsis may be more common than initially inferred, especially in CLL cases with adverse clinical outcome. Here, we review the main features of chromothripsis, the challenges of its assessment, and the potential benefit of its detection. We summarize recent findings of chromothripsis occurrence across hematological malignancies and address its causes and consequences in the context of CLL clinical features, as well as chromothripsis-related molecular abnormalities described in published CLL studies. Furthermore, we discuss the use of the current knowledge about genome functions associated with chromothripsis in the optimization of treatment strategies in CLL.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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