Immune system disorders in the early post-injury period in patients after severe brain injury from the perspective of the severity of the injury

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F23%3A00077286" target="_blank" >RIV/65269705:_____/23:00077286 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/23:00130201

Result on the web

<a href="https://link.springer.com/article/10.1007/s10072-022-06482-1" target="_blank" >https://link.springer.com/article/10.1007/s10072-022-06482-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10072-022-06482-1" target="_blank" >10.1007/s10072-022-06482-1</a>

Result language

angličtina

Original language name

Immune system disorders in the early post-injury period in patients after severe brain injury from the perspective of the severity of the injury

Original language description

Background Brain injuries are the most common cause of death in productive age. Besides the extent of the injury, other systemic factors can also affect the outcome. Patients suffering from severe brain injury often experience extracranial inflammatory complications during the early period of treatment. Here, we investigate the changes in immunity in patients with brain injury. Methods 121 patients and 92 healthy controls were included in the research. Blood samples were collected on admission and analyzed by flow cytometry and biochemical methods. Multiple clusters of differentiation (CD) and antibody levels were investigated. The results were compared between patients and controls. In addition, results of two classes of severity (Glasgow Coma Scale, GCS, of 3-5 vs. 6-8) were also compared. Results Parameters of humoral immunity in patients immediately after admission were significantly lower than those from healthy donors, with the exception of IgE elevated as much as to resemble allergic reaction (p &lt; 0.01). Of cellular parameters, only natural killer (NK) cluster CD56 + was elevated (p &lt; 0.01). Extracranial infectious complications were more common in patients with GCS 3-5. Conclusions Strong immune system disorders were observed in patients after severe brain injury, which may contribute to the worse outcome in such patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neurological Sciences

ISSN

1590-1874

e-ISSN

1590-3478

Volume of the periodical

44

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

1031-1038

UT code for WoS article

000881545900001

EID of the result in the Scopus database

2-s2.0-85141664766