Management of pheochromocytomas and paragangliomas: Review of current diagnosis and treatment options
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F23%3A00078029" target="_blank" >RIV/65269705:_____/23:00078029 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/23:00130968 RIV/61989592:15110/23:73619682 RIV/00098892:_____/23:10157887 RIV/00209805:_____/23:00079258
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1002/cam4.6010" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1002/cam4.6010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cam4.6010" target="_blank" >10.1002/cam4.6010</a>
Alternative languages
Result language
angličtina
Original language name
Management of pheochromocytomas and paragangliomas: Review of current diagnosis and treatment options
Original language description
Pheochromocytomas (PCCs) are rare neuroendocrine tumors derived from the chromaffin cells of the adrenal medulla. When these tumors have an extra-adrenal location, they are called paragangliomas (PGLs) and arise from sympathetic and parasympathetic ganglia, particularly of the para-aortic location. Up to 25% of PCCs/PGLs are associated with inherited genetic disorders. The majority of PCCs/PGLs exhibit indolent behavior. However, according to their affiliation to molecular clusters based on underlying genetic aberrations, their tumorigenesis, location, clinical symptomatology, and potential to metastasize are heterogenous. Thus, PCCs/PGLs are often associated with diagnostic difficulties. In recent years, extensive research revealed a broad genetic background and multiple signaling pathways leading to tumor development. Along with this, the diagnostic and therapeutic options were also expanded. In this review, we focus on the current knowledge and recent advancements in the diagnosis and treatment of PCCs/PGLs with respect to the underlying gene alterations while also discussing future perspectives in this field.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer Medicine
ISSN
2045-7634
e-ISSN
2045-7634
Volume of the periodical
12
Issue of the periodical within the volume
13
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
13942-13957
UT code for WoS article
000981618600001
EID of the result in the Scopus database
2-s2.0-85158078654