Clinical and laboratory diversity of diffuse large B-cell lymphomas in children with Nijmegen breakage syndrome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F23%3A00078430" target="_blank" >RIV/65269705:_____/23:00078430 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/23:00133398
Result on the web
<a href="https://haematologica.org/article/view/haematol.2022.282325" target="_blank" >https://haematologica.org/article/view/haematol.2022.282325</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3324/haematol.2022.282325" target="_blank" >10.3324/haematol.2022.282325</a>
Alternative languages
Result language
angličtina
Original language name
Clinical and laboratory diversity of diffuse large B-cell lymphomas in children with Nijmegen breakage syndrome
Original language description
Nijmegen breakage syndrome (NBS) is an inherited DNA repair disorder characterized by a high predisposition to develop lymphoid malignancies during childhood, with diffuse large B-cell lymphoma (DLBCL) being one of the leading types. Due to concomitant immunodeficiency and an increased risk of chemotherapy-induced toxicity, NBS patients often require modified and individualized cancer treatment. Nevertheless, they rarely achieve progressionand relapse-free long-term survival rates without hematopoietic stem cell transplantation. Unfavorable outcome of lymphomas in NBS may result not only from the reduction of drug dosages but could be associated with molecular aberrations occurring on the background of chromosomal instability. Therefore, we aimed to investigate clinical outcome, histopathological features, and genomic alterations of DLBCL in pediatric patients with NBS. The algorithm of the study is shown in the Online Supplementary Figure S1A.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Haematologica
ISSN
0390-6078
e-ISSN
1592-8721
Volume of the periodical
108
Issue of the periodical within the volume
10
Country of publishing house
IT - ITALY
Number of pages
6
Pages from-to
2808-2813
UT code for WoS article
001109389400020
EID of the result in the Scopus database
2-s2.0-85173573650