Facial emotion processing in patients with borderline personality disorder as compared with healthy controls: an fMRI and ECG study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F24%3A00079480" target="_blank" >RIV/65269705:_____/24:00079480 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/24:00135810

Result on the web

<a href="https://bpded.biomedcentral.com/articles/10.1186/s40479-024-00245-4" target="_blank" >https://bpded.biomedcentral.com/articles/10.1186/s40479-024-00245-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s40479-024-00245-4" target="_blank" >10.1186/s40479-024-00245-4</a>

Result language

angličtina

Original language name

Facial emotion processing in patients with borderline personality disorder as compared with healthy controls: an fMRI and ECG study

Original language description

BackgroundMaladaptive behaviors and interpersonal difficulties in patients with borderline personality disorder (BPD) seem connected to biased facial emotion processing. This bias is often accompanied by heightened amygdala activity in patients with BPD as compared to healthy controls. However, functional magnetic resonance imaging (fMRI) studies exploring differences between patients and healthy controls in facial emotion processing have produced divergent results. The current study explored fMRI and heart rate variability (HRV) correlates of negative facial emotion processing in patients with BPD and healthy controls.MethodsThe study included 30 patients with BPD (29 females; age: M = 24.22, SD = 5.22) and 30 healthy controls (29 females; M = 24.66, SD = 5.28). All participants underwent the &quot;faces&quot; task, an emotional face perception task, in an fMRI session simultaneously with ECG. In this task, participants are presented with emotional expressions of disgust, sadness, and fear (as a negative condition) and with the same pictures in a scrambled version (as a neutral condition).ResultsWe found no differences in brain activity between patients with BPD and healthy controls when processing negative facial expressions as compared to neutral condition. We observed activation in large-scale brain areas in both groups when presented with negative facial expressions as compared to neutral condition. Patients with BPD displayed lower HRV than healthy controls in both conditions. However, there were no significant associations between HRV and amygdala activity and BPD symptoms.ConclusionThe results of this study indicate no abnormal brain activity during emotional facial processing in patients with BPD. This result contrasts with previous studies and more studies are needed to clarify the relationship between facial emotion processing and brain activity in patients with BPD. Possible reasons for the absence of brain activity differences are discussed in the study. Consistent with previous findings, patients showed lower HRV than healthy controls. However, HRV was not associated with amygdala activity and BPD symptoms.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30215 - Psychiatry

Project

<a href="/en/project/NU20-04-00410" target="_blank" >NU20-04-00410: Neural mechanisms of dialectical behavioral therapy in patients with borderline personality disorder</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Borderline Personality Disorder and Emotion Dysregulation

ISSN

2051-6673

e-ISSN

2051-6673

Volume of the periodical

11

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

4

UT code for WoS article

001163103200001

EID of the result in the Scopus database

2-s2.0-85185340217