Human Endogenous Retroviruses in Breast Cancer: Altered Expression Pattern Implicates Divergent Roles in Carcinogenesis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F24%3A00080018" target="_blank" >RIV/65269705:_____/24:00080018 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/24:00136373 RIV/00216208:11110/24:10483029 RIV/00064165:_____/24:10483029

Result on the web

<a href="https://karger.com/ocl/article/doi/10.1159/000538021/896090/Human-Endogenous-Retroviruses-in-Breast-Cancer" target="_blank" >https://karger.com/ocl/article/doi/10.1159/000538021/896090/Human-Endogenous-Retroviruses-in-Breast-Cancer</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000538021" target="_blank" >10.1159/000538021</a>

Result language

angličtina

Original language name

Human Endogenous Retroviruses in Breast Cancer: Altered Expression Pattern Implicates Divergent Roles in Carcinogenesis

Original language description

Introduction: Breast cancer is the most common cancer and the leading cause of cancer death in women. Recent research indicates that human endogenous retroviruses (HERVs) may be linked to carcinogenesis, but the data remain controversial. Methods: HERVs&apos; expression was evaluated to show the differences between breast cancer and control samples, and their associations with clinicopathological parameters. Gene expression of 12 HERVs, i.e., ERVE-4, ERVW-1, ERVFRD-1, ERVV-1, ERV3-1, ERVH48-1, ERVMER34-1, ERVK-7, ERVK13-1, ERVK11-1, ERVK3-1, and HCP5, was analyzed by qPCR and/or TCGA datasets for breast cancer. Results: ERV3-1, ERVFRD-1, ERVH48-1, and ERVW-1 provided data to support their tumor suppressor roles in breast cancer. ERV3-1 evinced the best performing diagnostic data based on qPCR, i.e., AUC: 0.819 (p &lt; 0.0001), sensitivity of 72.41%, and specificity of 89.66%. Lower levels of ERV3-1 were noted in advanced stage and higher grades, and significant negative association was found in relation to Ki-67 levels. Oncogenic roles may be inferred for ERVK13-1, ERVV-1, and ERVMER34-1. Data for ERVK-7, ERVE-4, ERVK11-1, and HCP5 remain inconclusive. Conclusion: Differential HERV expression may be applicable to evaluate novel biomarkers for breast cancer. However, more research is needed to reveal their real clinical impact, the biological roles, and regulatory mechanisms in breast carcinogenesis. (c) 2024 The Author(s).Published by S. Karger AG, Basel

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oncology

ISSN

0030-2414

e-ISSN

1423-0232

Volume of the periodical

102

Issue of the periodical within the volume

10

Country of publishing house

CH - SWITZERLAND

Number of pages

10

Pages from-to

858-867

UT code for WoS article

001243070800001

EID of the result in the Scopus database

2-s2.0-85194734601