First evidence of murid gammaherpesvirus 4 (MHV-68) virus in the blood of oncological patients

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F25%3A00082364" target="_blank" >RIV/65269705:_____/25:00082364 - isvavai.cz</a>
Result on the web
<a href="https://www.frontierspartnerships.org/journals/acta-virologica/articles/10.3389/av.2025.14168/full" target="_blank" >https://www.frontierspartnerships.org/journals/acta-virologica/articles/10.3389/av.2025.14168/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/av.2025.14168" target="_blank" >10.3389/av.2025.14168</a>

Result language
angličtina
Original language name
First evidence of murid gammaherpesvirus 4 (MHV-68) virus in the blood of oncological patients
Original language description
Murid gammaherpesvirus 4 (prototype strain MHV-68) is a natural pathogen of murid rodents that is able to transform lymphocytes and induce lymphoproliferative diseases and tumor transformation in their host cells. Considering that this virus can infect and multiply in various human cell lines, we think it could also play an important role in the pathogenesis of some human types of cancer. We investigated and confirmed the presence of the replication and transcription activator rta (ORF 50) from MHV-68 virus in four peripheral blood samples from patients with lymphomas and gliomas.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10607 - Virology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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