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WrbA bridges bacterial flavodoxins and eukaryotic NAD(P)H: quinone oxidoreductases

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67179843%3A_____%2F07%3A00098102" target="_blank" >RIV/67179843:_____/07:00098102 - isvavai.cz</a>

  • Alternative codes found

    RIV/60076658:12640/07:00008308

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    WrbA bridges bacterial flavodoxins and eukaryotic NAD(P)H: quinone oxidoreductases

  • Original language description

    The crystal structure of the flavodoxin-like protein WrbA with oxidized FMN bound reveals a close relationship to mammalian NAD(P) H:quinone oxidoreductase, Nqo1. Structural comparison of WrbA, flavodoxin, and Nqo1 indicates how the twisted open-sheet fold of flavodoxins is elaborated to form multimers that extend catalytic function from one-electron transfer between protein partners using FMN to two-electron reduction of xenobiotics using FAD. The structure suggests a novel physiological role for WrbAand Nqo1.

  • Czech name

    WrbA jako pojítko mezi bakteriálními flavodoxiny a eukaryotními NAD(P)H:chinon oxidoreduktázami

  • Czech description

    Krystalová struktura proteinu WrbA podobného flavodoxinům s oxidovaným FMN vykazuje blízky vztah k savčím NAD(P)H:chinon oxidoreduktázam, Nqo1. Strukturní srovnání WrbA, flavodoxinů a Nqo1 ukazuje, jak svinuté foldování flavodoxinů napomáhá tvořit multimery, které umožňují rozšířit katalytickou funkci z jednoelektronového přechodu u proteinů s navázaným FMN na dvouelektronovou redukci xenobiotik obsahujících FAD. Struktura navrhuje novou fyziologickou roli pro WrbA a Nqo1

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CF - Physical chemistry and theoretical chemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2007

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Protein Science

  • ISSN

    0961-8368

  • e-ISSN

  • Volume of the periodical

    10

  • Issue of the periodical within the volume

    16

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    5

  • Pages from-to

    2301-2305

  • UT code for WoS article

  • EID of the result in the Scopus database