Two-photon polarization microscopy reveals protein structure and function

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67179843%3A_____%2F11%3A00371057" target="_blank" >RIV/67179843:_____/11:00371057 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12640/11:43882316 RIV/68407700:21340/11:00209253
Result on the web
<a href="http://dx.doi.org/10.1038/NMETH.1643" target="_blank" >http://dx.doi.org/10.1038/NMETH.1643</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/NMETH.1643" target="_blank" >10.1038/NMETH.1643</a>

Result language
angličtina
Original language name
Two-photon polarization microscopy reveals protein structure and function
Original language description
Membrane proteins are a large, diverse group of proteins, serving a multitude of cellular functions. They are difficult to study because of their requirement of a lipid membrane for function. Here we show that two-photon polarization microscopy can takeadvantage of the cell membrane requirement to yield insights into membrane protein structure and function, in living cells and organisms. The technique allows sensitive imaging of G-protein activation, changes in intracellular calcium concentration and other processes, and is not limited to membrane proteins. Conveniently, many suitable probes for two-photon polarization microscopy already exist.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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