Robust Image Analysis of BeadChip Microarrays

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F15%3A00438102" target="_blank" >RIV/67985807:_____/15:00438102 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21460/15:00231275 RIV/00216208:11110/15:10322994
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Robust Image Analysis of BeadChip Microarrays
Original language description
Microarray images in molecular genetics are heavily contaminated by noise and outlying measurements. This paper is devoted to analysis of Illumina BeadChip microarray images, primarily to their low-level preprocessing. We point out that standard image analysis procedures, which are implemented in the beadarray package of BioConductor software, are highly sensitive to contamination by severe noise and outliers. Therefore, the habitually used methodology does not discover many of the outliers. We illustrate this on real data and show that the standard background correction method may actually amplify the noise in the image. A robust image analysis tailor-made for this type of microarray images is highly desirable. We explain principles and show preliminary results of our robust alternative to the standard approach, which aims to be robust to noise and outliers in each its step.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
BIOIMAGING 2015. Proceedings of the International Conference on Bioimaging
ISBN
978-989-758-072-7
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
89-94
Publisher name
Scitepress
Place of publication
Lisbon
Event location
Lisbon
Event date
Jan 12, 2015
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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