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Role of gamma knife radiosurgery in the treatment of prolactinomas

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F19%3A00506301" target="_blank" >RIV/67985807:_____/19:00506301 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/19:10395721 RIV/00216208:11120/19:43918390 RIV/00064173:_____/19:N0000113 RIV/00023884:_____/19:00008166 RIV/00064165:_____/19:10395721

  • Result on the web

    <a href="http://dx.doi.org/10.1007/s11102-019-00971-x" target="_blank" >http://dx.doi.org/10.1007/s11102-019-00971-x</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s11102-019-00971-x" target="_blank" >10.1007/s11102-019-00971-x</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Role of gamma knife radiosurgery in the treatment of prolactinomas

  • Original language description

    Purpose: Stereotactic radiosurgery is one of the treatment options for prolactinomas, the most commonly used being Gamma Knife Radiosurgery (GKRS). GKRS is indicated mainly in the treatment of dopamine agonist (DA)-resistant prolactinomas. In our study, we report on our experience in treating prolactinoma patients by GKRS. Methods: Twenty-eight patients were followed-up after GKRS for 26–195 months (median 140 months). Prior to GKRS, patients were treated with DAs and 9 of them (32.1%) underwent previous neurosurgery. Cavernous sinus invasion was present in 16 (57.1%) patients. Indications for GKRS were (i) resistance to DA treatment (17 patients), (ii) drug intolerance (5 patients), or (iii) attempts to reduce the dosage and/or shorten the length of DA treatment (6 patients). Results: After GKRS, normoprolactinaemia was achieved in 82.1% of patients, out of which hormonal remission (normoprolactinaemia after discontinuation of DAs) was achieved in 13 (46.4%), and hormonal control (normoprolactinaemia while taking DAs) in 10 (35.7%) patients. GKRS arrested adenoma growth or decreased adenoma size in all cases. Two patients (8.3%) developed hypopituitarism after GKRS. Prolactinoma cystic transformation with expansive behaviour, manifested by bilateral hemianopsia, was observed in one patient. Conclusions: GKRS represents an effective treatment option, particularly for DA-resistant prolactinomas. Normoprolactinaemia was achieved in the majority of patients, either after discontinuation of, or while continuing to take, DAs. Tumour growth was arrested in all cases. The risk of the development of hypopituitarism can be limited if the safe dose to the pituitary and infundibulum is maintained.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30202 - Endocrinology and metabolism (including diabetes, hormones)

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Pituitary

  • ISSN

    1386-341X

  • e-ISSN

  • Volume of the periodical

    22

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    411-421

  • UT code for WoS article

    000475566500011

  • EID of the result in the Scopus database

    2-s2.0-85067862182