Association Between Apelin and Atrial Fibrillation in Patients With High Risk of Ischemic Stroke
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F21%3A00546972" target="_blank" >RIV/67985807:_____/21:00546972 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3389/fcvm.2021.742601" target="_blank" >http://dx.doi.org/10.3389/fcvm.2021.742601</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fcvm.2021.742601" target="_blank" >10.3389/fcvm.2021.742601</a>
Alternative languages
Result language
angličtina
Original language name
Association Between Apelin and Atrial Fibrillation in Patients With High Risk of Ischemic Stroke
Original language description
BACKGROUND: Atrial fibrillation (AF) is associated with high risk of stroke preventable by timely initiation of anticoagulation. Currently available screening tools based on ECG are not optimal due to inconvenience and high costs. Aim of this study was to study the diagnostic value of apelin for AF in patients with high risk of stroke. METHODS: We designed a multicenter, matched-cohort study. The population consisted of three study groups: a healthy control group (34 patients) and two matched groups of 60 patients with high risk of stroke (AF and non-AF group). Apelin levels were examined from peripheral blood. RESULTS: Apelin was significantly lower in AF group compared to non-AF group (0.694 ± 0.148 vs. 0.975 ± 0.458 ng/ml, p = 0.001) and control group (0.982 ± 0.060 ng/ml, p < 0.001), respectively. Receiver operating characteristic (ROC) analysis of apelin as a predictor of AF scored area under the curve (AUC) of 0.658. Apelin's concentration of 0.969 [ng/ml] had sensitivity = 0.966 and specificity = 0.467. Logistic regression based on manual feature selection showed that only apelin and NT-proBNP were independent predictors of AF. Logistic regression based on selection from bivariate analysis showed that only apelin was an independent predictor of AF. A logistic regression model using repeated stratified K-Fold cross-validation strategy scored an AUC of 0.725 ± 0.131. CONCLUSIONS: Our results suggest that apelin might be used to rule out AF in patients with high risk of stroke.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Cardiovascular Medicine
ISSN
2297-055X
e-ISSN
2297-055X
Volume of the periodical
8
Issue of the periodical within the volume
October 2021
Country of publishing house
CH - SWITZERLAND
Number of pages
10
Pages from-to
742601
UT code for WoS article
000713254800001
EID of the result in the Scopus database
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