Plasmatic apelin shows a promising potential as a screening biomarker for atrial fibrillation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F23%3A00573133" target="_blank" >RIV/67985807:_____/23:00573133 - isvavai.cz</a>
Result on the web
<a href="https://dx.doi.org/10.4149/BLL_2023_056" target="_blank" >https://dx.doi.org/10.4149/BLL_2023_056</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/BLL_2023_056" target="_blank" >10.4149/BLL_2023_056</a>
Alternative languages
Result language
angličtina
Original language name
Plasmatic apelin shows a promising potential as a screening biomarker for atrial fibrillation
Original language description
OBJECTIVES: Purpose of this study was to evaluate properties of apelin, a peptide detectable in peripheral blood, for atrial fibrillation (AF) detection in a diverse population of patients covering a broad spectrum from healthy to polymorbid patients. BACKGROUND: AF is the most common cardiac arrhythmia with constantly increasing incidence and prevalence. Currently available diagnostic tools do not provide sufficient detection rate. Large proportion of patients with AF remains undiagnosed and the possibility of screening at-risk groups would be significantly beneficial. METHODS: We designed this study as a multi-centre retrospective study. Study population included 183 patients. 64 in non-AF and 119 in AF group. RESULTS: Apelin plasma concentration was significantly lower in AF group compared to non-AF group (p < 0.001). Receiver operating characteristic analysis of apelin as a predictor of AF scored area under the curve of 0.79, sensitivity = 0.941 and specificity = 0.578. Multivariate analysis using logistic regression adjusted for age, BMI, apelin, dilated LV, dilated LA, arterial hypertension, and gender showed only apelin and age to be statistically significant contributors for AF. CONCLUSION: Apelin might be a promising biomarker for detecting AF in our study population. These results suggest promising potential of apelin as a screening biomarker for AF (Tab. 2, Fig. 1, Ref. 46).
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bratislavske Lekarske Listy
ISSN
0006-9248
e-ISSN
1336-0345
Volume of the periodical
124
Issue of the periodical within the volume
5
Country of publishing house
SK - SLOVAKIA
Number of pages
5
Pages from-to
368-372
UT code for WoS article
000978786500006
EID of the result in the Scopus database
2-s2.0-85152244416