Tremor associated with similar structural networks in Parkinson's disease and essential tremor
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F22%3A00550746" target="_blank" >RIV/67985807:_____/22:00550746 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/22:00077784 RIV/00216208:11110/22:10441729 RIV/00064165:_____/22:10441729 RIV/00216224:14110/22:00128076
Result on the web
<a href="http://dx.doi.org/10.1016/j.parkreldis.2021.12.014" target="_blank" >http://dx.doi.org/10.1016/j.parkreldis.2021.12.014</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.parkreldis.2021.12.014" target="_blank" >10.1016/j.parkreldis.2021.12.014</a>
Alternative languages
Result language
angličtina
Original language name
Tremor associated with similar structural networks in Parkinson's disease and essential tremor
Original language description
Introduction: Despite substantial clinical and pathophysiological differences, the characteristics of tremor in Parkinson's disease (PD) and essential tremor (ET) patients bear certain similarities. The presented study delineates tremor-related structural networks in these two disorders. Methods: 42 non-advanced PD patients (18 tremor-dominant, 24 without substantial tremor), 17 ET, and 45 healthy controls underwent high-angular resolution diffusion-weighted imaging acquisition to reconstruct their structural motor connectomes as a proxy of the anatomical interconnections between motor network regions, implementing state-of-the-art globally optimised probabilistic tractography. Results: When compared to healthy controls, ET patients exhibited higher structural connectivity in the cerebello-thalamo-cortical network. Interestingly, the comparison of tremor-dominant PD patients and PD patients without tremor yielded very similar results – higher structural connectivity in tremor-dominant PD sharing multiple nodes with the tremor network detected in ET, despite the generally lower structural connectivity between basal ganglia and frontal cortex in the whole PD group when compared to healthy controls. Conclusion: The higher structural connectivity of the cerebello-thalamo-cortical network seems to be the dominant tremor driver in both PD and ET. While it appears to be the only tremor-related network in ET, its combination with large scale hypoconnectivity in the frontal cortico-subcortical network in PD may explain different clinical features of tremor in these two disorders.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Parkinsonism & Related Disorders
ISSN
1353-8020
e-ISSN
1873-5126
Volume of the periodical
95
Issue of the periodical within the volume
February 2022
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
28-34
UT code for WoS article
000749847700006
EID of the result in the Scopus database
2-s2.0-85121972553