Analysis of Complications and Recipients' and Graft Survival in Patients 60 Years of Age and Older in the Long-Term Follow-up Period After Kidney Transplant: A Single-Center, Paired Kidney Analysis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F22%3A00558619" target="_blank" >RIV/67985807:_____/22:00558619 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.transproceed.2022.03.038" target="_blank" >http://dx.doi.org/10.1016/j.transproceed.2022.03.038</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.transproceed.2022.03.038" target="_blank" >10.1016/j.transproceed.2022.03.038</a>

Result language

angličtina

Original language name

Analysis of Complications and Recipients' and Graft Survival in Patients 60 Years of Age and Older in the Long-Term Follow-up Period After Kidney Transplant: A Single-Center, Paired Kidney Analysis

Original language description

BACKGROUND: Long-term results of kidney transplant (KTx) in older patients may differ from younger recipients owing to increased cardiovascular comorbidities. The study aimed to analyze surgical and nonsurgical complications that develop in the long-term follow-up period after KTx, and factors that influence results of KTx in recipients aged 60 years and older (≥60) compared with younger recipients (<60). METHODS: One hundred seventy-five patients aged ≥60 years and 175 patients aged <60 years who received a kidney graft from the same deceased donor were enrolled in the study. In the long-term follow-up period (3 months to 5 years after KTx) the incidence of surgical and nonsurgical complications, as well as patient and kidney graft survival, were compared. Additionally, the influence of early complications on patients and kidney graft survival was assessed. RESULTS: There were no differences between recipients aged ≥60 years compared with recipients aged <60 years in occurrence of surgical complications (graft artery stenosis: 0.6% vs 2.3%, ureter stenosis: 3.4% vs 1.1%, lymphocele: 6.9% vs 3.4%) and nonsurgical complications (urinary tract infection: 19.4% vs 23.4%, pneumonia: 8.6% vs 8.6%, cytomegalovirus infection: 6.3% vs 8%, new-onset diabetes after transplant: 16.6% vs 17.1%, cancer incidence: 5.7% vs 4.6%, acute rejection episode: 13.1% vs 17.1%). Five-year recipient survival was lower in a group of patients aged ≥60 years (death, 15.4% vs 8%, death with functioning graft, 12% vs 5.1%). CONCLUSIONS: The incidence of surgical and nonsurgical complications, as well as kidney-graft survival, in recipients aged ≥60 years in a 5-year follow-up period is comparable to younger recipients aged <60 years. As the mean population age is growing, there is a rising number of patients aged more than 60 years registering as potential kidney graft recipients [1]. In 2020, there were 813 potential kidney recipients who were older than 60 years of age registered on the National Transplant Registry's waiting list for kidney transplant in Poland. This was about 38.7% of all patients awaiting kidney transplant [2]. Older age is related to multimorbidity, especially cardiovascular diseases, diabetes mellitus, and cancer. It is highly possible that owing to the mentioned comorbidities, older recipients will present poorer outcomes of kidney transplant (KTx), and more often they will develop postoperative complications, regardless of donor factors influence [3], [4], [5]. However, in our previous study, we proved that in the early postoperative period the rates of postoperative complications after KTx, kidney graft function, and the patient's kidney-graft survival in those aged 60 years are similar to younger recipients [6]. The credibility of these results was achieved by the application of kidney-paired analysis, which diminishes the influence of donor factors. Nevertheless, it cannot be excluded that the mentioned comorbidities and complications that develop in the early postoperative period after KTx will impact the outcomes of KTx in the older recipients in the long-term follow-up period [3,[7], [8], [9]]. The study aimed to analyze the following: surgical and nonsurgical complications that develop in the long-term follow-up period after kidney transplant, patients and kidney graft survival, and the influence of early complications on the results of kidney transplant in recipients aged 60 years and older (≥60) compared with younger recipients (<60).

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30213 - Transplantation

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Transplantation Proceedings

ISSN

0041-1345

e-ISSN

1873-2623

Volume of the periodical

54

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

948-954

UT code for WoS article

000887139200025

EID of the result in the Scopus database

2-s2.0-85133268523