Milling of pharmaceutical powder carrier excipients: Application of central composite design
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F22%3A00565992" target="_blank" >RIV/67985807:_____/22:00565992 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/22:10451062
Result on the web
<a href="https://dx.doi.org/10.1016/j.apt.2022.103881" target="_blank" >https://dx.doi.org/10.1016/j.apt.2022.103881</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.apt.2022.103881" target="_blank" >10.1016/j.apt.2022.103881</a>
Alternative languages
Result language
angličtina
Original language name
Milling of pharmaceutical powder carrier excipients: Application of central composite design
Original language description
Pharmaceutical powder carriers are often used to prevent agglomeration of a micronized drug in the co-milling process. Twenty-four pharmaceutical excipients were subjected to preliminary mild milling conditions in this work. Ten of them showed acceptable milling properties with alginic acid, calcium alginate, microcrystalline cellulose (Avicel® 200), carrageenan, and hypromellose having the best particle size reduction without any aggregation while maintaining a narrow span. For the latter five substances, circumscribed central composite design (CCD) evaluating the effect of the factors milling speed and timeon the responses (particle size, particle size distribution) for three milling ball sizes was used to establish optimal milling conditions. For all ten possible factor combinations and each ball size, a quadratic response surface model was used to predict the response variable. For three substances out of five, the best results were achieved using 5-mm balls. Thermal characteristics showed the good stability of excipients under optimized milling conditions.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Powder Technology
ISSN
0921-8831
e-ISSN
1568-5527
Volume of the periodical
33
Issue of the periodical within the volume
12
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
9
Pages from-to
103881
UT code for WoS article
000892295100007
EID of the result in the Scopus database
2-s2.0-85142135929