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Milling of pharmaceutical powder carrier excipients: Application of central composite design

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F22%3A00565992" target="_blank" >RIV/67985807:_____/22:00565992 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11160/22:10451062

  • Result on the web

    <a href="https://dx.doi.org/10.1016/j.apt.2022.103881" target="_blank" >https://dx.doi.org/10.1016/j.apt.2022.103881</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.apt.2022.103881" target="_blank" >10.1016/j.apt.2022.103881</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Milling of pharmaceutical powder carrier excipients: Application of central composite design

  • Original language description

    Pharmaceutical powder carriers are often used to prevent agglomeration of a micronized drug in the co-milling process. Twenty-four pharmaceutical excipients were subjected to preliminary mild milling conditions in this work. Ten of them showed acceptable milling properties with alginic acid, calcium alginate, microcrystalline cellulose (Avicel® 200), carrageenan, and hypromellose having the best particle size reduction without any aggregation while maintaining a narrow span. For the latter five substances, circumscribed central composite design (CCD) evaluating the effect of the factors milling speed and timeon the responses (particle size, particle size distribution) for three milling ball sizes was used to establish optimal milling conditions. For all ten possible factor combinations and each ball size, a quadratic response surface model was used to predict the response variable. For three substances out of five, the best results were achieved using 5-mm balls. Thermal characteristics showed the good stability of excipients under optimized milling conditions.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30104 - Pharmacology and pharmacy

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Advanced Powder Technology

  • ISSN

    0921-8831

  • e-ISSN

    1568-5527

  • Volume of the periodical

    33

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    9

  • Pages from-to

    103881

  • UT code for WoS article

    000892295100007

  • EID of the result in the Scopus database

    2-s2.0-85142135929