Milling of pharmaceutical powder carrier excipients: Application of central composite design

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F22%3A00565992" target="_blank" >RIV/67985807:_____/22:00565992 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/22:10451062

Result on the web

<a href="https://dx.doi.org/10.1016/j.apt.2022.103881" target="_blank" >https://dx.doi.org/10.1016/j.apt.2022.103881</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.apt.2022.103881" target="_blank" >10.1016/j.apt.2022.103881</a>

Result language

angličtina

Original language name

Milling of pharmaceutical powder carrier excipients: Application of central composite design

Original language description

Pharmaceutical powder carriers are often used to prevent agglomeration of a micronized drug in the co-milling process. Twenty-four pharmaceutical excipients were subjected to preliminary mild milling conditions in this work. Ten of them showed acceptable milling properties with alginic acid, calcium alginate, microcrystalline cellulose (Avicel® 200), carrageenan, and hypromellose having the best particle size reduction without any aggregation while maintaining a narrow span. For the latter five substances, circumscribed central composite design (CCD) evaluating the effect of the factors milling speed and timeon the responses (particle size, particle size distribution) for three milling ball sizes was used to establish optimal milling conditions. For all ten possible factor combinations and each ball size, a quadratic response surface model was used to predict the response variable. For three substances out of five, the best results were achieved using 5-mm balls. Thermal characteristics showed the good stability of excipients under optimized milling conditions.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Advanced Powder Technology

ISSN

0921-8831

e-ISSN

1568-5527

Volume of the periodical

33

Issue of the periodical within the volume

12

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

9

Pages from-to

103881

UT code for WoS article

000892295100007

EID of the result in the Scopus database

2-s2.0-85142135929