Edoxaban for Stroke Prevention in Atrial Fibrillation and Age-Adjusted Predictors of Clinical Outcomes in Routine Clinical Care
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F23%3A00560446" target="_blank" >RIV/67985807:_____/23:00560446 - isvavai.cz</a>
Result on the web
<a href="https://dx.doi.org/10.1093/ehjcvp/pvac042" target="_blank" >https://dx.doi.org/10.1093/ehjcvp/pvac042</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/ehjcvp/pvac042" target="_blank" >10.1093/ehjcvp/pvac042</a>
Alternative languages
Result language
angličtina
Original language name
Edoxaban for Stroke Prevention in Atrial Fibrillation and Age-Adjusted Predictors of Clinical Outcomes in Routine Clinical Care
Original language description
AIMS: Patients with atrial fibrillation (AF) treated with oral anticoagulation still suffer from cardiovascular complications including cardiovascular death, stroke, and major bleeding. To identify risk factors for predicting stroke and bleeding outcomes in anticoagulated patients, we assessed 2-year outcomes in patients with AF treated with edoxaban in routine care. We also report the age-adjusted risk predictors of clinical outcomes. METHODS AND RESULTS: The Edoxaban Treatment in Routine Clinical Practice for Patients With Non-Valvular Atrial Fibrillation (ETNA-AF) Europe (NCT02944019) is a prospective, multi-centre, post-authorisation, observational study with an overall 4-year follow-up conducted in 825 centres enrolling edoxaban-treated patients in 10 European countries. Of the 13 133 patients with AF (mean age: 73.6 ± 9.5 years), 5682 (43.3%) were female. At the 2-year follow-up, 9017/13 133 patients were still on edoxaban, 1830 discontinued treatment including 937 who died (annualised event rate of all-cause death was 3.87%). 518 (2.14%) patients died of cardiovascular causes, 234 (0.97%) experienced major bleeding and 168 (0.70%) experienced stroke or systemic embolic events (SEE). Intracranial haemorrhage was noted in 49 patients (0.20%). History of transient ischaemic attack (TIA) at baseline was the strongest predictor of ischaemic stroke or SEE (Wald χ2: 73.63, P < 0.0001). Low kidney function at baseline was the strongest predictor of major bleeding (Wald χ2: 30.68, P < 0.0001). History of heart failure (HF) was the strongest predictor of all-cause (Wald χ2: 146.99, P < 0.0001) and cardiovascular death (Wald χ2: 100.38, P < 0.0001). CONCLUSION: Patients treated with edoxaban in ETNA-AF-Europe reported low 2-year event rates in unselected AF patients. Prior stroke, reduced kidney function, and HF identify patients at high risk of stroke, bleeding and all-cause/cardiovascular death, respectively.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Heart Journal-Cardiovascular Pharmacotherapy
ISSN
2055-6837
e-ISSN
2055-6845
Volume of the periodical
9
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
47-57
UT code for WoS article
000836165300001
EID of the result in the Scopus database
2-s2.0-85144586435