Prescribing Patterns and Outcomes of Edoxaban in Atrial Fibrillation Patients From Asia - One-Year Data From the Global ETNA-AF Program

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F24%3A00587413" target="_blank" >RIV/67985807:_____/24:00587413 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1253/circrep.CR-23-0098" target="_blank" >https://doi.org/10.1253/circrep.CR-23-0098</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1253/circrep.CR-23-0098" target="_blank" >10.1253/circrep.CR-23-0098</a>

Result language

angličtina

Original language name

Prescribing Patterns and Outcomes of Edoxaban in Atrial Fibrillation Patients From Asia - One-Year Data From the Global ETNA-AF Program

Original language description

BACKGROUND: This study reports prescribing patterns and the 1-year effectiveness and safety of edoxaban in an Asian cohort of Edoxaban Treatment in routiNe clinical prActice (ETNA)-Atrial Fibrillation (AF) patients. METHODS AND RESULTS: The Global ETNA-AF program integrates prospective, observational, noninterventional regional studies, collecting data on characteristics and clinical outcomes of patients with AF receiving edoxaban for stroke prevention. Baseline characteristics, medical history, and 1-year clinical event rates were assessed in patients from South Korea, Taiwan, Hong Kong, and Thailand. Clinically relevant events assessed at 12 months included all-cause death, cardiovascular death, ischemic and hemorrhagic stroke, systemic embolic events (SEEs), bleeding, and net clinical outcome (NCO). Overall, 3,359 patients treated with edoxaban 60 or 30 mg once daily completed 1-year follow-up, 70.9% of patients received recommended dosing according to local labels. Baseline mean±standard deviation age was 71.7±9.6 years, CHA2DS2-VASc score was 3.1±1.5, and modified HAS-BLED score was 2.3±1.1. Mean age and sex were similar across countries/regions. The 1-year event rate for all-cause death was 1.8%, major bleeding, 1.3%, ischemic stroke, 1.1%, cardiovascular mortality, 0.7%, hemorrhagic stroke, 0.3%, SEEs, 0%, and NCO, 4.1% ,with differences observed between countries/regions and dosing groups. CONCLUSIONS: Most Asian patients with AF were prescribed recommended edoxaban dosing in routine care settings. At 1-year follow-up, this analysis supports the effectiveness and safety of edoxaban in these patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Circulation Reports

ISSN

2434-0790

e-ISSN

2434-0790

Volume of the periodical

6

Issue of the periodical within the volume

3

Country of publishing house

JP - JAPAN

Number of pages

8

Pages from-to

86-93

UT code for WoS article

001283270900007

EID of the result in the Scopus database

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