Pro-ictal, rather than pre-ictal, brain state marked by global critical slowing and local gamma power increase

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F25%3A00635636" target="_blank" >RIV/67985807:_____/25:00635636 - isvavai.cz</a>

Alternative codes found

RIV/00023752:_____/25:43921554 RIV/00216208:11130/25:10498655

Result on the web

<a href="https://doi.org/10.1016/j.clinph.2025.2110742" target="_blank" >https://doi.org/10.1016/j.clinph.2025.2110742</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clinph.2025.2110742" target="_blank" >10.1016/j.clinph.2025.2110742</a>

Result language

angličtina

Original language name

Pro-ictal, rather than pre-ictal, brain state marked by global critical slowing and local gamma power increase

Original language description

OBJECTIVE: The pre-surgical evaluation of epilepsy relies on the electrophysiological recordings of spontaneous seizures. During this period drug dose decreases increase the likelihood of seizures transitioning the brain from a low to high seizure likelihood state, so-called pro-ictal state. This study aimed to identify the dynamic brain changes characteristic of this transition from 386 ten-minute segments of intracranial EEG recordings of 29 patients with drug-refractory temporal lobe epilepsy. METHODS: We studied brain dynamics through mean phase locking value and relative power in gamma band, and autocorrelation function width. We further explored interactions with pro-ictal factors, such as rate of interictal spikes and high frequency oscillations, circadian and multi-day cycles, and clinical outcomes. RESULTS: We observed significant increases in gamma power in the epileptogenic zone, and critical slowing in both the epileptogenic zone and presumably healthy cortex. These changes were linked with increases in spike and high frequency oscillations rate. CONCLUSIONS: Brain dynamics changed on the slow time scale – from the beginning to the end of the multi-day interval – but did not change in the short-term during the pre-ictal interval, thus could reflect pro-ictal changes. SIGNIFICANCE: We highlight gamma power and critical slowing indices as markers of pro-ictal brain states, as well as their potential to track the seizure-related brain mechanisms during the presurgical evaluation of epilepsy patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Neurophysiology

ISSN

1388-2457

e-ISSN

1872-8952

Volume of the periodical

175

Issue of the periodical within the volume

July 2025

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

13

Pages from-to

2110742

UT code for WoS article

001506318400001

EID of the result in the Scopus database

2-s2.0-105007310431