Ictal Gamma-Band Interactions Localize Ictogenic Nodes of the Epileptic Network in Focal Cortical Dysplasia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F21%3A00543462" target="_blank" >RIV/67985823:_____/21:00543462 - isvavai.cz</a>
Alternative codes found
RIV/67985807:_____/21:00543462 RIV/00023752:_____/21:43920629 RIV/00216208:11130/21:10428678 RIV/68407700:21230/21:00350090 RIV/00064203:_____/21:10428678
Result on the web
<a href="http://dx.doi.org/10.1016/j.clinph.2021.04.016" target="_blank" >http://dx.doi.org/10.1016/j.clinph.2021.04.016</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.clinph.2021.04.016" target="_blank" >10.1016/j.clinph.2021.04.016</a>
Alternative languages
Result language
angličtina
Original language name
Ictal Gamma-Band Interactions Localize Ictogenic Nodes of the Epileptic Network in Focal Cortical Dysplasia
Original language description
Objective: Epilepsy surgery fails in > 30% of patients with focal cortical dysplasia (FCD). The seizure persistence after surgery can be attributed to the inability to precisely localize the tissue with an endogenous potential to generate seizures. In this study, we aimed to identify the critical components of the epileptic network that were actively involved in seizure genesis. Methods: The directed transfer function was applied to intracranial EEG recordings and the effective connectivity was determined with a high temporal and frequency resolution. Pre-ictal network properties were compared with ictal epochs to identify regions actively generating ictal activity and discriminate them from the areas of propagation. Results: Analysis of 276 seizures from 30 patients revealed the existence of a seizure-related network reconfiguration in the gamma-band (25–170 Hz, p < 0.005) – ictogenic nodes. Unlike seizure onset zone, resecting the majority of ictogenic nodes correlated with favorable outcomes (p < 0.012). Conclusion: The prerequisite to successful epilepsy surgery is the accurate identification of brain areas from which seizures arise. We show that in FCD-related epilepsy, gamma-band network markers can reliably identify and distinguish ictogenic areas in macroelectrode recordings, improve intracranial EEG interpretation and better delineate the epileptogenic zone. Significance: Ictogenic nodes localize the critical parts of the epileptogenic tissue and increase the diagnostic yield of intracranial evaluation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Neurophysiology
ISSN
1388-2457
e-ISSN
1872-8952
Volume of the periodical
132
Issue of the periodical within the volume
8
Country of publishing house
IE - IRELAND
Number of pages
10
Pages from-to
1927-1936
UT code for WoS article
000674175200021
EID of the result in the Scopus database
2-s2.0-85109523613