Resting EEG partial coherence demonstrates increased γ range central functional connectivity in amnestic mild cognitive impairment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F25%3A00641461" target="_blank" >RIV/67985807:_____/25:00641461 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.brainres.2025.149973" target="_blank" >https://doi.org/10.1016/j.brainres.2025.149973</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.brainres.2025.149973" target="_blank" >10.1016/j.brainres.2025.149973</a>
Alternative languages
Result language
angličtina
Original language name
Resting EEG partial coherence demonstrates increased γ range central functional connectivity in amnestic mild cognitive impairment
Original language description
OBJECTIVE: Relatively little is known about EEG high gamma (gamma) range changes in Alzheimer's disease (AD). We investigated functional connectivity, focusing on the gamma range, in amnestic Mild Cognitive Impairment (MCI) using ordinary Coherence (COH) and Partial Coherence (PCOH), a metric which enhances signal-to-noise ratio at high frequencies. METHODS: MCI (N=21) and Cognitively Normal (CN, N=62) ALBION study participants had resting EEG with eyes closed (EC) and eyes open (EO) in 10/20 montage (19 active electrodes). COH and PCOH in 0.5-100 Hz for each subject were calculated for all 171 electrode pairs. RESULTS: In both gamma1 (30-50 Hz) and gamma2 (50-100 Hz) ranges, PCOH was significantly higher in MCI than in CN in several electrode pairs, especially centrally, in both eye conditions. Concerning local (average of each electrode) connectivity, MCI compared to CN showed significantly higher values in PCOH centrally. CONCLUSIONS: Resting EEG gamma range functional connectivity at central areas, as revealed by PCOH, is significantly higher in MCI than in CN. SIGNIFICANCE: Gamma range local and regional EEG functional connectivity differences may help construct useful and easily available biomarkers in neurodegeneration. Metrics such as PCOH, which factor out global connectivity components, may help reveal such differences.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Brain Research
ISSN
0006-8993
e-ISSN
1872-6240
Volume of the periodical
1867
Issue of the periodical within the volume
November 2025
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
17
Pages from-to
149973
UT code for WoS article
001588444200001
EID of the result in the Scopus database
2-s2.0-105017631471