Genetic isolation of a blood pressure quantitative trait locus on chromosome 2 in the spontaneously hypertensive rat

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F01%3A00000099" target="_blank" >RIV/67985823:_____/01:00000099 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/01:00142137

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Genetic isolation of a blood pressure quantitative trait locus on chromosome 2 in the spontaneously hypertensive rat

Original language description

The objective of the current study was to directly test for the presence of a blood pressure QTL on rat chromosome 2. A new congenic strain was derived by replacing a segment of chromosome 2 in the SHR between D2Rat171 and D2Arb24 with the correspondingchromosome segment from the normotensive Brown Norway rat. Arterial pressures were directly monitored in conscious rats by radiotelemetry. We found that the SHR congenic strain (SHR-2) carrying a segment of chromosome 2 from the Brown Norway rat had significantly lower systolic and diastolic blood pressures than the SHR progenitor strain. The attenuation of hypertension in the SHR-2 congenic strain versus the SHR progenitor strain was accompanied by significant amelioration of cardiac hypertrophy. Thesefindings demonstrate that gene(s) with major effects on blood pressure exist in the differential segment of chromosome 2 trapped within the new SHR.BN congenic strain

Czech name

Genetická izolace lokusu kvantitativních znaků pro krevní tlak na chromozomu 2 u spontánně hypertenzních potkanů

Czech description

Vazebné analýzy BXH/HXB rekombinantních inbredních kmenů naznačily, že důležitá genetická varianta pro regulaci krevního tlaku se nachází na chromozomu 2 SHR potkanů. Tato hypotéza byla potvrzena přenosem úseku chromozomu 2 z kmene BN na genetické pozadíkmene SHR. Nový kongenní kmen měl významně nižší krevní tlak a redukovanou hypertrofii levé komory srdeční

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Hypertension

ISSN

0263-6352

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

4

Pages from-to

1061-1064

UT code for WoS article

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EID of the result in the Scopus database

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