Stimuli that induce a cholinergic neuronal phenotype of NG108-15 cells upregulate ChAT and VAChT mRNAs but fail to increase VAChT protein.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F01%3A20010189" target="_blank" >RIV/67985823:_____/01:20010189 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Stimuli that induce a cholinergic neuronal phenotype of NG108-15 cells upregulate ChAT and VAChT mRNAs but fail to increase VAChT protein.

Original language description

Neuronal cholinergic phenotype is charecterized by the expression of the enzyme choline acetyltransferase and of the vesicular acetylcholine transporter. Various differentiation treatments were shown to enhance neuronal phenotype of cholinergic NG108-15cells and to increase the transcription of 'cholinergic gene locus' and the expression of functional choline acetyltransferase. None treatment, however, could induce the expression of the mature vesicular acetylcholine transporter. This observations suggest that posttranslational control play important role in the expression of the vesicular acetylcholine transporter.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

—

Project

<a href="/en/project/GA305%2F98%2F0469" target="_blank" >GA305/98/0469: Mechanism and possibilities of pharmacological intervention in presynaptic regulation of acetycholine release</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Brain Research Bulletin

ISSN

0361-9230

e-ISSN

—

Volume of the periodical

54

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

363-373

UT code for WoS article

—

EID of the result in the Scopus database

—