Cell cycle perturbations induced by Cisplatin in normal and tumor transformed cells.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F01%3A20010233" target="_blank" >RIV/67985823:_____/01:20010233 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Cell cycle perturbations induced by Cisplatin in normal and tumor transformed cells.
Original language description
Cisplatin (cis-dichlorodiamineplatinum II) is a cytostatic used for treatment of tumors, including those of the brain. Molecular mechanisms of cell cycle effect of this drug are not entirely understood. In this study we compared the cell cycle changes induced by Cisplatin in tumor transformed rat C6 glioma cells and normal dividing rat brain cells, as represented by glial cells in cultures and germinative cells of the immature cerebellum exposed to the drug in situ. In normal cells, we found an early and profound alerting of the G1-phase checking point while changes in G2/M-phase compartment were much lower and found only in the cells exposed to Cisplatin in situ. In tumor transformed C6 glioma cells the G2/M checking point was found to be main, and/or, the only mechanism responding to Cisplatin. In addition, the number of G2/M blocked cells in C6 glioma cultures was remarkably increasing with time which indicates great intrapopulation heterogeneity in the efficiency of cell cycle cont
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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