Toxicity, uptake and retention of sodium mercaptoborate (BSH) in glial and glioma cells in culture

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F97%3A00004073" target="_blank" >RIV/00216224:14310/97:00004073 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Toxicity, uptake and retention of sodium mercaptoborate (BSH) in glial and glioma cells in culture

Original language description

Growth, morphology and viability of C6 glioma cells were significantly altered only in fast growing cultures exposed to supratherapeutic doses of BSH (sodium mercaptoborate) for 48 to 72 h. Inhibition of cell proliferation and loss of semipermeability ofplasma membrane of cells exposed to toxic doses of BSH were followed by apoptotic fragmentation of DNA in a small part of population. In the remaining lethally damaged cells the process of cell-destruction appeared to be inhibited. the higher uptake ofBSH by transformed glial cells suggests that the BSH content in brain tumours in situ may be controlled not only by deffects in the hematoencephalic barrier but also by tumour cellphenotype.

Czech name

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Czech description

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Type

B - Specialist book

CEP classification

ED - Physiology

OECD FORD branch

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Project

<a href="/en/project/NF5161" target="_blank" >NF5161: Radiosurgical lesion of the rat hippocampus using the Leksell gamma knife: relation between radiation dose and functional and structural damage.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

1997

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

ISBN

24-229-570

Number of pages

6

Publisher name

Elsevier Scince B.V.

Place of publication

Nizozemsko

UT code for WoS book

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