Subcellular targets of mercaptoborate (BSH), a carrier of 10B for neutron capture therapy (BNCT) of brain tumors.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F03%3A20030105" target="_blank" >RIV/67985823:_____/03:20030105 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Subcellular targets of mercaptoborate (BSH), a carrier of 10B for neutron capture therapy (BNCT) of brain tumors.

Original language description

The transformed C6 glial cells in cultures were treated with sodium mercaptoborate (Na2B12H11SH, BSH), a carrier of atomic targets (10B) of thermal neutrons for the Neutron Capture Therapy (NCT) of brain tumors. The therapeutic dose of BSH (100 micro g/ml) did not alter gross morphology and growth of the population of cells while activation of nucleoli and enlargment of mitochondria was revelaed by electron microscopy. After 200 micro g BSH/ml cell population growth was inhibited, the nuclear chromatinwas more condensed and allocated to the nuclear envelope which formed deeper invaginations. Mitochondria further increased in size and the circumscribed segments their cristae disappeared or were reduced to fine pouch-like structures near the continuousouter membrane, suggestive for a non-destructive restructuring of the inner mitochondrial membrane. The smooth pinocytotic vesicles near the plasma membrane, lysosomes and heterogeneous dense bodies were more frequent. The revealed subcel

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/FD-K%2F048" target="_blank" >FD-K/048: Research and development of techniques and equipments for application of ionising radiation in industry and human medicine.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

52

Issue of the periodical within the volume

5

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

629-635

UT code for WoS article

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EID of the result in the Scopus database

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