Mitochondrial uncoupling proteins and phylogenesis - UCP4 as the ancestral uncoupling protein.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F01%3A20010256" target="_blank" >RIV/67985823:_____/01:20010256 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Mitochondrial uncoupling proteins and phylogenesis - UCP4 as the ancestral uncoupling protein.
Original language description
We searched for the previously defined uncoupling protein (UCP) signatures [Je'ek P. and Urb nkov , E. (2000) IUBMB Life 49, 63-70] in genomes of Drosophila melanogaster, Caenorhabditis elegans, Dictyostelium discoideum, and Arabidopsis thaliana. We identified four UCPs in Drosophila and one in Caenorhabditis or Dictyostelium as close relatives of human UCP4 (BMCP), but distant from UCP1, UCP2, UCP3, and two plant UCPs of Arabidopsis. But the third Arabidopsis UCP is the closest UCP4 relative. This suggests that UCP4 represents the ancestral UCP form from which other mammalian and plat UCPs diverged. It is surprising in the light of the fact that in humans UCP4 is brain-specific protein. Speculations on UCP4 participation in apoptosis are thus supported by its early phylogenetic occurrence.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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