Chronic exposure of NG108-15 cells to amyloid beta peptide (A beta(1-42)) abolishes calcium influx via N-type calcium channels.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F01%3A20010276" target="_blank" >RIV/67985823:_____/01:20010276 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Chronic exposure of NG108-15 cells to amyloid beta peptide (A beta(1-42)) abolishes calcium influx via N-type calcium channels.

Original language description

We investigated whether amyloid- -peptide (A 1-42) has an effect on the elevations of the intracellular concentration of Ca2+ ions ([Ca2+]i ) induced by depolarizations of NG108-15 cells and on related Ca2+ channels. A 1-42 (10 - 1000 nM) had no immediate effect on depolarization-induced [Ca2+]i elevations. [Ca2+]i increases were slightly diminished in cells grown in the presence of 100 or 1000 nM A 1-42. Nifedipine (1 M) reduced these elevations equally in cells grown in the absence or presence of A 1-42. In contrast, the ability of ?-conotoxin GVIA to diminish the depolarization-induced [Ca2+]i responses became lost in cells grown in the presence of 100 nM A 1-42. This indicates that the influx of calcium through the N-type Ca2+ channels was compromised by the chronic exposure of cells to a submicromolar concentration of A 1-42 , presumably because of impairement of their function or diminished expression. This may be important in the pathogeny of Alzheimer s dementia in view of the

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

—

Project

<a href="/en/project/NF5183" target="_blank" >NF5183: Effects of beta-amyloid on the function of cholinergic synapses.</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neurochemical Research

ISSN

0364-3190

e-ISSN

—

Volume of the periodical

26

Issue of the periodical within the volume

8-9

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

1079-1084

UT code for WoS article

—

EID of the result in the Scopus database

—