Effects of mitochondrial KATP modulators on cardioprotection induced by chronic high altitude hypoxia in rats.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F02%3A20020057" target="_blank" >RIV/67985823:_____/02:20020057 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Effects of mitochondrial KATP modulators on cardioprotection induced by chronic high altitude hypoxia in rats.
Original language description
Adaptation of rats to chronic hypoxia increases the tolerance of their hearts to acute ischemia/reperfusion injury. Administration of a selective blocker of mitochondrial ATP sensitive potassium channels (KATP) 5-hydroxydecanoate abolished cardioprotective effects of chronic hypoxia; administration of selective KATP channels openers (diazoxide and BMS 191095) induced protection in normoxic hearts and but did not influence hypoxic heart. The results suggest that opening of mitochondrial KATP channels isinvolved in the cardioprotective mechanism conferred by long-term adaptation to chronic hypoxia.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cardiovascular Research
ISSN
0008-6363
e-ISSN
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Volume of the periodical
55
Issue of the periodical within the volume
3
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
9
Pages from-to
567-575
UT code for WoS article
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EID of the result in the Scopus database
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