Experimental photodynamic therapy with MESO-tetrakisphenylporphyrin (TPP) in liposomes leads to disintegration of human amelanotic melanoma implanted to nude mice.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F03%3A20030005" target="_blank" >RIV/67985823:_____/03:20030005 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Experimental photodynamic therapy with MESO-tetrakisphenylporphyrin (TPP) in liposomes leads to disintegration of human amelanotic melanoma implanted to nude mice.

Original language description

Liposomal meso-tetrakis-phenylporphyrin (TPP) was tested for photodynamic therapy (PDT) of human amelanotic melanomas implanted to nude mice. After intratumoural TPP application (15 mg.kg-1) followed by PDT lamp irradiation (600 - 700 nm, 635 nm peak) tumours retained their original volume up to the 23rd day post PDT, whereas volumes increased six times in controls. PDT with intravenously (iv.) administered liposomal (3.2 mg.kg-1) TPP mostly disintegrated tumours to zero volumes. Melanoma remissions were accompanied by tumour surface necroses and were documented by the appearance of nontumourous cells with non-pycnotic nuclei. Spatial arrangement of capillaries in remising tumour was the same as in healthy surrounding tissue. Lower TPP doses (1, 0.3, and 0.1 mg.kg-1) were more or equally efficient than hydrophilic TPPS4 (3.2 mg.kg-1, i.e. sulfonated TPP), iv. administered also in liposomes. Liposomal TPPS4 only delayed the onset of subsequent tumour growth. Commercial Photosan 3 disint

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Cancer

ISSN

0020-7136

e-ISSN

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Volume of the periodical

103

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

693-702

UT code for WoS article

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EID of the result in the Scopus database

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