Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F04%3A00102571" target="_blank" >RIV/67985823:_____/04:00102571 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity
Original language description
Thiochrome binds to all muscarinic receptor subtypes but allosterically enhances affinity for acetylcholine only at M4 subtype in both binding and functional assays. These results demonstrate a new absolute form of subtype specificity which is derived from cooperativity rather than from affinity
Czech name
Thiochrom zvyšuje afinitu pro acetylcholin u muskarinových M4 receptorů: podtypová selektivita na základě kooperativity spíše než afinity
Czech description
Thiochrom se váže na všechny podtypy muskarinových receptorů, ale alostericky zvyšuje afinitu pro acetylcholin jak ve vazebných, tak ve funkčních pokusech pouze u podtypu M4. Tyto výsledky ukazují nový absolutní druh specificity pro subtypy receptoru, která závisí na kooperativitě a ne na afinitě
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular Pharmacology
ISSN
0026-895X
e-ISSN
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Volume of the periodical
65
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
257-266
UT code for WoS article
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EID of the result in the Scopus database
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