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20-oxo-5beta-pregnan-3alpha-yl sulfate is a use-dependent NMDA receptor inhibitor

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F05%3A00024112" target="_blank" >RIV/67985823:_____/05:00024112 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    20-oxo-5beta-pregnan-3alpha-yl sulfate is a use-dependent NMDA receptor inhibitor

  • Original language description

    20-oxo-5beta-pregnan-3alpha-yl sulfate (3alfa5betaS) is a use-dependent but voltage-independent inhibitor of NMDA receptors that exerts its effect by reducing the peak Po of NMDA receptor channels. Its inhibitory action is weaker for responses mediated by NMDA receptors activated by synaptically released glutamate than those tonically activated by the agonist

  • Czech name

    20-oxo-5beta-pregnan-3alpha-yl sulfát je inhibitor NMDA receptorů závislý na jejich aktivaci

  • Czech description

    20-oxo-5beta-pregnan-3alpha-yl sulfát (3alfa5betaS) je inhibitor NMDA receptorů, jehož působení závisí na aktivaci NMDA receptorů. 3alfa5betaS inhibuje iontové kanály NMDA receptorů snižováním pravděpodobnosti jejich otevírání. Inhibiční účinky 3alfa5betaS jsou menší u proudových odpovědí NMDA receptorů, které jsou aktivované glutamátem uvolněným během synaptického přenosu, než receptorů aktivovaných tonicky

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    ED - Physiology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2005

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Neuroscience

  • ISSN

    0270-6474

  • e-ISSN

  • Volume of the periodical

    25

  • Issue of the periodical within the volume

    37

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    12

  • Pages from-to

    8439-8450

  • UT code for WoS article

  • EID of the result in the Scopus database